1-TDC™ gel is a FANTASTIC adjunct to assist in the treatment of gingivitis and periodontal disease. 1-TDC™ is also used to promote Joint Health. See www.1-TDC.co.uk for more details.
Oral inflammation is a frustrating difficult condition to try and control in our pets. An essential part of control is a proper assessment and treatment by a qualified veterinary surgeon with an interest in oral health.
1-TDC™ has been shown to have benefits in helping to decrease the destructive inflammatory processes in periodontal disease. It will never be the “magic bullet” that means no other treatment is necessary – but it can significantly help control this painful and debilitating condition. 1-TDC™ gel is a novel blend of esterified monounsaturated fatty acids, which can simply be applied to the gums by lifting the lip and squeezing the capsule contents onto the upper jaw. Most cats and dogs seem to like the taste, they certainly don’t often resist application. The active ingredients are very rapidly absorbed through the gums – getting high active concentrations just where it is needed. The rest of the capsule can be simply swallowed.
For joint health use of 1-TDC™ seems to provide increased mobility and comfort. The unique blend of Esterified Fatty Acid Complexes (EFACs) delivers results that seem far superior to traditional joint health solutions and fish oils. When 1-TDC™ is used to help with joint disease the capsules can simply be given whole, orally.
When inflammation occurs most of the body’s responses are helpful in correcting the cause of the problem. However, some of the inflammatory changes can be destructive. This unwanted destructive reaction is especially important in periodontal disease – where bone loss can lead to loosening of teeth and their loss. In the joints inflammation leads to cartilage damage and changes in the joint lining.
The unique 1-TDC™ mixture of esterified monounsaturated fatty acids seems to help suppress these destructive processes. Research work is still ongoing to determine the precise biological pathways, but the beneficial results are clear to see and have been reported in leading scientific publications for Periodontology and Rheumatology.
My dog - a 9 year old border collie - was getting very stiff after a walk or a training session. She had had several short treatments of the usual anti-inflammatory help, with no lasting effect. After a week of 1-TDC she was managing to get up after a sleep without being stiff and now, after 3 months, the improvement is lasting. Added to this, her teeth and gums are strong and healthy. I will definitely continue to give her this very effective product. I am amazed at the improvements this product continues to give.
Jane S (Switzerland)
“I perform orthopaedic surgery every day in my practice. I firmly believe in the benefits of combining 1-TDC™ with NSAIDs and Tramadol to improve the clinical outcome in my patients. I see it work every day”
Dr Jeff Mayo
Fellow of the North American Academy of Veterinary Orthopedic Surgery
DVM, CVLS, Diplomate American Board of Veterinary Practice Companion Animal Specialist
“Based on a study I performed at the University of Saskatchewan, I was amazed at the positive results from the use of the 1-TDC™ technology. All periodontal measurements in the test animals improved significantly. The more I use the 1-TDC™ technology, the more impressed I am. It is not the total answer to oral health but it is a tremendous aid.”
Dr James Anthony
Specialist Veterinary Dentist
BSc(Agr), DVM, MRCVS, FAVD, DAVDC, Diplomate EVDC, PAg
1-TDC is an esterified MonoUnsaturated Fatty Acid mixture of cetylmyristoleate, cetyl myristate, cetyl palmitoleate, cetyl laureate, cetyl palmitate and cetyl oleate.
Topical 1-TDC in the Treatment of Periodontal Disease in Cats
Dr. James Anthony: Pacific Dental Service for Animals, Princeton, BC
Results - Clinical Observations
1-Tetradecanol Complex: Therapeutic Actions in Experimental Periodontitis
J Periodontol • July 2009: Hasturk, Goguet-Surmenian, Blackwood, Andry, Kantarci
There is substantial evidence that the products of arachidonic acid (AA) metabolism may be pivotal in triggering and perpetuating the inflammatory changes seen in periodontitis. High concentrations of some of these chemicals are particularly destructive and implicated in periodontal diseases.
Manipulation of the immune response to suppress unwanted inflammatory reactions has been widely studied as a treatment for controlling such inflammatory responses in periodontal disease. Fatty acids have been proposed to reduce chronic inflammation by reducing the release of chemicals from stimulated white blood cells.
Treatment with 1-TDC resulted in a significant reduction in inflammation and bone loss compared to baseline periodontitis.
1-TDC treatment for periodontitis resulted in periodontal bone gain, whereas sites treated with placebo or left untreated had bone loss.
1-TDC treatment significantly reduced the inflammatory cell infiltration
The results indicate that 1-TDC™ is capable of reversing inflammation in periodontitis. These findings and the normal characteristics of newly formed bone in the 1-TDC™ sections suggested that 1-TDC™ was able to stop the progression of the disease and initiate healing, leading to bone reformation.
1-TDC™ treatment further initiates healing and the reformation of periodontal tissue integrity lost as a result of inflammation.
Although the precise mechanisms underlying these actions of 1-TDC™ remain to be elucidated, it is clear that dietary fatty acids have the potential to alter the level of inflammation. The therapeutic use of topically applied fatty acid preparations has significant clinical potential.
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